Your Cancer Guide – Through The Lens of Apoptosis & The Mitochondria

By Zaid K. Dahhaj

If we want to understand cancer, we need to understand the central role mitochondria play in this crucial cellular process. There are many different forms of cancer that act in different ways.

But, people who have done their homework can agree on one thing:

Cancer is fundamentally a consequence of chronically broken apoptosis.

 

Now, you might be lost when you hear the word ‘apoptosis,’ but I aim to clarify the basics of that process here and tie it to the cancer discussion.

The question arises, what is apoptosis?

Apoptosis is a form of programmed cell death that occurs in multicellular organisms like human beings. It is a controlled process in which cells undergo an orderly death to eliminate old, unnecessary, or damaged cells without causing harm to the surrounding tissue. This process is essential for maintaining healthy tissue homeostasis and is involved in various physiological and developmental processes, such as:

    • Development: Apoptosis shapes organs and tissues during embryonic development by removing unnecessary cells
    • Immune System: It helps in the maturation of immune cells and the elimination of harmful or dysfunctional cells, which is central to the subject of cancer development
    • Cell Turnover: Apoptosis maintains balance by removing old or damaged cells and allowing new cells to replace them
    • Disease Prevention: It prevents the proliferation of potentially cancerous cells by eliminating cells with damaged DNA

It goes hand in hand with autophagy, which is cellular process in which cells degrade and recycle their own components. The term “autophagy” comes from the Greek words “auto” meaning self and “phagy” meaning eating.

By removing damaged proteins and organelles, autophagy can prevent the accumulation of cellular debris that can lead to chronic diseases such as cancer.

The illustration below gives you a good idea of what occurs to cells when your lifestyle doesn’t allow for the correct functioning of both apoptosis and autophagy.

In other words, when these two processes become dysfunctional over time through chronic circadian disruption, it opens the doors for healthy cells to become cancerous ones.

Apoptosis - a review of programmed cell death

Now you might ask, what controls apoptosis? The mitochondria.

The mitochondrial pathways of apoptosis

Cell death - All roads lead to mitochondria

Once again, we find ourselves at the heart of cellular function which explains so much of health and disease. The mitochondria are key to understanding how cancer manifests in the first place. They are the keystone pillar of biology and biophysics.

I quote from the “The mitochondrial pathway of apoptosis“:

“Although for a long time the absence of mitochondrial changes was considered as a hallmark of apoptosis, mitochondria appear today as the CENTRAL EXECUTIONER of apoptosis.”

 

This should make your ears perk up if you know somebody close to you who has dealt with cancer, or if you have been diagnosed with it yourself. I know this strikes close to home for many of you because cancer is a world destroying chronic disease that is at the top of the list of leading global killers.

What I urge you to do is channel your curiosity into understanding this article. Have an open mind.

What I’m about to lay out for you isn’t explained by any of the centralized oncologists today, and will even be pointed out as fringe by many of them, even though my understanding of this is grounded in the current scientific literature in combination with how the body works.

All forms of cancer come down to chronic dysfunction in the process of apoptosis (programmed cell death). Cancers can act differently and have a number of contributing factors, but at its root, you’ll find that apoptosis doesn’t work the way it should.

I don’t care what cancer you’re talking about:

    • Breast cancer
    • Brain cancer
    • Lung cancer
    • Colorectal cancer
    • Skin cancer
    • Stomach cancer
    • Testicular cancer

If you don’t give your body room to clean up damaged cells, then the body becomes a breeding ground for those cells to mutate and multiply, which then creates the conditions for cancer to manifest.

Going back to the mitochondria, these light sensing mechanisms are loaded with red light chromophores in the electron transport chain and evolved to sense natural electromagnetic frequencies (EMFs), rather than man-made EMFs.

And so, we find ourselves back at the light and electromagnetism story to explain the root cause of mitochondrial dysfunction.

I’ve commented in the past on how Complex V (the ATP Synthase), in particular, of the electron transport chain, contains quantum nano motors that spin efficiently only when they’re given the right environment to thrive: red/near-infrared light from the sun and free electrons via nutrient-dense, low-deuterium food, and through grounding.

Zaid K. Dahhaj on X: "Every mitochondria in your body uses red and NIR light to power its ATPase nano-motors The electron transport chain of mitochondria depends on sunlight How is it

These are Mother Nature’s most efficiently designed biological nano machines that have evolved to work through billions of years of evolutionary adaptation and iteration. If you break these nano motors through an unhealthy, circadian disrupting lifestyle, then you destroy the function of the mitochondria.

Considering the sheer amount of mitochondria we have in the body, this can explain why cancer takes time to manifest in many cases. Cancer is generally not a manifestation because of some acute circumstance, although it can be in specific cases.

It is typically a gradual process that results from a lifetime of harming the mitochondria through poor lifestyle choices. It doesn’t come from the breakdown of nuclear DNA in the majority of cases as you’ve been told, but from the breakdown of mitochondrial DNA.

Even in cases where a child has a severe and aggressive form of cancer, we can point to mitochondrial heteroplasmy at its root, a mutation in mitochondrial DNA that manifests spontaneously or is passed down from the mother.

What is mitochondrial DNA fundamentally controlled by? Circadian biology.

The approach, or lack thereof, you take with your circadian rhythm and light environment plays the biggest role in this discussion of cancer.

If you avoid the sun and artificially manipulate its spectrum via sunglasses, sunscreen, tanning beds, being behind windows, makeup, and contact lenses, you are drastically increasing your risk of developing cancer in one form or the other.

Being behind windows that aren’t open, in particular, is a major cause of skin cancer because of the way conventional glass manipulates the full light spectrum in harmful ways.

It blocks UV-B, the majority of the red and infrared spectrum, while focusing UV-A and blue light wavelengths untouched. The study below gives you an idea of what biological consequences this combination can create.

Increased UVA exposures and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma

If you live under artificial light 24/7, especially after sunset, then you’re inviting cancer to come into your life. Artificial blue light on its own destroys the non-visual photoreceptors, alters the function of melanocytes, and annihilates the mitochondria which are central to apoptosis. As mentioned before, altered light conditions also drive skin cancer.

.Induction of Skin Cancer by Long Term Blue Light Irradiation

Circadian dysfunction is THE heavy hitter here.

Artificial light at night is the most powerful way to destroy your circadian rhythm, and the results found in the scientific literature of its broad-reaching damage are shocking.

Here we have artificial light at night being shown to CAUSE cancer in human beings.

Artificial Light at Night and Cancer - Global Study

Artificial Light at Night and Cancer - Global Study - Discussion

We also have a lot of valid research showing its destructive impact on metabolism, blood sugar regulation, neurodegeneration, heart disease, and much more.

Man-made EMFs are another story due to the impact these non-native frequencies have on mitochondrial function and the homeostasis of the skin’s function. But there are also more important considerations here.

Sun-avoidance and “protection”, which has been shoved down your throat since you were a child, further fuels your skyrocketing risk for cancers. Why is that?

Because of chronic Vitamin D3 deficiency. Vitamin D3 from UV-B light, which is only received during mid-morning to mid-afternoon sunbathing comes with a host of health benefits, most notably its ability to fight cancer effectively.

So much so, that you can even track cancer rates with latitude. Cancer incidence is higher the further you live away from the equator. Also, studies have found that the most serious cases of cancer are diagnosed in winter. This is true, for example, for colorectal cancer.

Colorectal cancer incidence rates, by latitude, males

The trend doesn’t just apply to colorectal cancer. It also applies to breast cancer (see below). Breast and colorectal cancer are distinctly different cancers, so in order for these graphs to be as similar as they are, there must a common denominator of extremely broad applicability underlying the latitude trend. And there is. It turns out the common denominator is vitamin D.

Breast cancer incidence rates, by latitude, females

Vitamin D3 has been shown to influence the expression of genes involved in autophagy. For example, the activation of the vitamin D receptor (VDR) by its ligand, calcitriol (the active form of Vitamin D3), can upregulate the expression of autophagy-related genes like ATG5, ATG7, and LC3.

The mammalian target of rapamycin (mTOR) pathway is a crucial regulator of autophagy. Vitamin D3 can modulate this pathway, promoting autophagy by inhibiting mTOR activity under certain conditions. This inhibition is important as mTOR negatively regulates autophagy; thus, its inhibition promotes the formation of autophagosomes.

Autophagosomes are crucial because they play a central role in stimulating autophagy, the recycling of damaged and potentially cancerous cells. If you are chronically deficient in vitamin D3 (like most people) because you don’t sunbathe consistently, you aren’t producing enough of these autophagosomes, which means your body isn’t in a position to fight potentially cancerous cells.

Vitamin D3 deficiency also causes major dysfunction in apoptosis.

Roles of Solar UVB and Vitamin D in Reducing Cancer Risk and Increasing Survival

I’m not done though.

By not sunbathing properly at the right times, you are also not getting enough of the subcellular melatonin that your mitochondria produce. What do we know about endogeneous melatonin?

It’s one of the most potent anti-cancer molecules within us:

    • Melatonin is a potent antioxidant that scavenges free radicals and reduces oxidative stress, which can contribute to cancer development and progression. By protecting cellular components from oxidative damage, melatonin prevents the initiation and progression of cancer
    • Melatonin can promote apoptosis (programmed cell death) in cancer cells. It helps activate apoptotic pathways, leading to the selective elimination of damaged or cancerous cells without affecting normal cells
    • Melatonin has been shown to inhibit the proliferation of various cancer cell lines. It can interfere with the cell cycle, leading to cell cycle arrest, and thereby slowing down the growth and spread of cancer cells
    • Chronic inflammation is a known risk factor for cancer. Melatonin possesses anti-inflammatory properties, reducing the production of pro-inflammatory cytokines and inhibiting inflammatory pathways that can contribute to cancer development
    • Angiogenesis, the formation of new blood vessels, is essential for tumor growth and metastasis. Melatonin has been found to inhibit angiogenesis, thereby restricting the blood supply to tumors and limiting their growth

And so here we find ourselves at the intersection of Vitamin D3 and endogenous melatonin produced from sunbathing, both of which are the most powerful anti-cancer compounds.

There’s also special consideration for artificial light at night because that form of toxic lighting destroys the second form of endogenous melatonin which is produced from your pineal gland that is triggered by darkness after sunset.

Now you’re beginning to understand the true value of this work.

If you’re going to say fuck cancer, then you better etch this information into your psyche and ACT on it by getting more sunlight, sunbathing properly by building your solar callus (see section on smart sun exposure in the Circadian app), and blocking artificial light ruthlessly (especially after sunset).

Protect your circadian rhythm at all costs. There is no mystery as to why cancer rates have been skyrocketing considering darker forces have electrified this world the wrong way and shoved anti-sun propaganda down your throat.

Don’t say I didn’t educate you.

Much love, Zaid.

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